Endocrine Abstracts

Introduction: The incidence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing within the paediatric community, prompting searches for a simple and effective screening tool. Oral glucose tolerance test (OGTT) is the gold standard but is poorly accessible in the community. HbA1c offers an alternative which can be easily performed, but cut-offs for children have been extrapolated directly from the adult American Diabetes Association (ADA) diagnostic criter...

Background: The UK Newborn Screening Programme Centre Clinical Referral Standards and Guidelines for CHT (2013) define TSH cut-offs for screen positive (>20 mU/l) and borderline (>10 and <20 mU/l) results. In Manchester levels >8 and <20 mU/l are classified as borderline. This audit aims to assess whether adopting the national cut-off would result in babies with significant and permanent hypothyroid disease being missed.Patient popula...

Background: The diagnosis of growth hormone deficiency (GHD) is based on a combination of clinical suspicion supported by growth hormone stimulation testing. IGF-1 and IGFBP-3 are used as supportive markers. Reports over the last decade have examined the performance of IGF-I and IGFBP-3 in the diagnosis of GHD. It is important that each unit evaluates the utility of these markers in the assay used by their laboratory based on relevant normative data.Aim:...